水を還元剤として用いた選択的二酸化炭素変換のための光触媒及び二元系助触媒の開発

京都大学新制・課程博士博士(工学)甲第23389号工博第4881号新制||工||1763(附属図書館)京都大学大学院工学研究科分子工学専攻(主査)教授 田中 庸裕, 教授 今堀 博, 教授 佐藤 徹学位規則第4条第1項該当Doctor of Philosophy (Engineering)Kyoto UniversityDFA

MOLECULAR MECHANISMS OF AGING IN THE PERIPHERAL NOCICEPTIVE SYSTEM

MOLECULAR MECHANISMS OF AGING IN THE PERIPHERAL NOCICEPTIVE SYSTEM Shuying Wang MD, PhD University of Pittsburgh, 2006 Decreased pain sensitivity during aging is common in humans and animals and is largely due to changes in anatomical, functional and cellular properties of the peripheral nervous system (PNS). To understand the molecular mechanisms of aging in the PNS, a detailed comparative study was made of 6~8week-, 16month- and 2year-old Blk6 male mice obtained from the NIA mouse colony. Behavioral assays showed aged mice had decreased sensitivity to noxious heat and impaired inflammation-induced thermal hyperalgesia compared to young animals. To understand the basis for this change we examined expression of the growth factor artemin, its receptor GFRα3 and TRPV1, an ion channel expressed by 95~99% of GFRα3-positive sensory neurons. TRPV1 is of significance since it is required for transmission of thermal hyperalgesia following tissue inflammation. Assays showed a reduction in TRPV1 mRNA and protein in the PNS of aged mice that correlated with a decrease in expression of the artemin receptor GFRα3, CFA-induced inflammation also increased artemin expression in the skin but decreased expression of GFRα3 in the dorsal root ganglia (DRG) of both young and old mice. The decrease in GFRα3 was greater in aged mice, suggesting GFRα3 signaling following CFA is reduced in sensory ganglia of old mice and that the response properties of GFRα3-positive sensory neurons that express TRPV1 are diminished. Calcium imaging of isolated primary neurons grown with NGF was used to test the in vitro effects of artemin on TRPV1 expression and activation in young and old neurons. Artemin potentiated TRPV1 activation by capsaicin in both young and old neurons, but the amplitude of capsaicin responses in young neurons was decreased with long-term exposure to artemin. Microarray and RT-PCR studies revealed that inflammation-associated genes such as interleukin 6 (IL-6) were elevated in sensory ganglia of aged mice. This ongoing inflammatory state may increase the inflammatory tone of the system and thereby contribute to changes in response properties and sensitivity of sensory neurons in the aging PNS. Thus, the reduced sensitivity to inflammatory pain in aged animals likely reflects a combination of changes in anatomical, physiologic and immune response properties

Agent-based workflow model for enterprise collaboration

Workflow management system supports the automation of business processes where a collection of tasks is organized between participants according to a defined set of rules to accomplish some business goals. The service-orientated computing paradigm is transforming traditional workflow management from a close, centralized control system into a dynamic information exchange and business process. Moreover, agent based workflow, from another point of view, provides a flexible mechanism for dynamic workflow coordination at run time. In this context, the combination of Web services and software agents provides great flexibility to discover and establish relationships among business partners. This thesis proposes an agent-based workflow model in support of inter-enterprise workflow management. In the proposed model, agent-based technology enables the workflow coordination at both inter- and intra- enterprise levels while semantic Web and Web services based technologies provide infrastructures for messaging, service description, service discovery, workflow ontology, and workflow enactment. Coordination agents and resource agents are used with a Contract Net protocol based bidding mechanism for constructing a dynamic workflow process among business partners. The agent system architecture, workflow models and related components are described. A prototype system is implemented for the purpose of designing and developing role-feasible agents for simulating the formation process of a virtual enterprise

A Slurry Consolidation Approach to Reconstitute Low-Plasticity Silt Specimens for Laboratory Triaxial Testing

Silt Specimen Reconstitution using a Slurry Consolidation Approach is Commonly Used for Laboratory Testing. This Paper Presents a New Slurry Consolidation Approach to Reconstitute Silt Specimens for Use in Triaxial Testing. Silt Specimens Were Reconstituted in a Split Vacuum Mold Mounted on a Special Experimental Setup. the Uniformity of the Reconstituted Specimens Was Verified by Measuring the Water Content and Grain Size Distribution throughout the Specimens. the Testing Program Was Expedited using a Special Sample Handling Technique to Move the Specimen from the Special Experimental Setup to the Triaxial Chamber Base Platen. the Handling Process Did Not Disturb the Specimens to a Measurable Degree. Further, the Replicas of the Reconstituted Specimens Were Verified by Submitting Them to Basic Volumetric Measurements Followed by Static and Cyclic Triaxial Tests. the Triaxial Test Results Reported Very Small Differences. Copyright © by ASTM Int\u27l (All Rights Reserved)

Extension of Object-Oriented Metrics Suite for

Software developers require information to understand the characteristics of systems, such as complexity and maintainability. In order to further understand and determine characteristics of object-oriented (OO) systems, this paper describes research that identifies attributes that are valuable in determining the difficulty in implementing changes during maintenance, as well as the possible effects that such changes may produce. A set of metrics are proposed to quantify and measure these attributes. The proposed complexity metrics are used to determine the difficulty in implementing changes through the measurement of method complexity, method diversity, and complexity density. The paper establishes impact metrics to determine the potential effects of making changes to a class and dependence metrics that are used to measure the potential effects on a given class resulting from changes in other classes. The case study shows that the proposed metrics provide additional information not sufficiently provided by the related existing OO metrics. The metrics are also found to be useful in the investigation of large systems, correlating with project outcomes

Numerical Simulation on Thermal Energy Storage Behavior of Cu/paraffin nanofluids PCMs

AbstractPCMs have foreseeable applications in residential buildings for effective use of solar energy. Paraffin is cheap and has moderate thermal energy storage density but low thermal conductivity. In this paper, we numerically investigate the melting processes of Cu/paraffin nanofluids PCMs. The results strongly suggested that the phase change heat transfer of paraffin was enhanced due to the addition of nanoparticles. For 1 wt% Cu/paraffin, the melting time can be saved 13.1%. The numerical results have a good agreement with the experimental results in describing the melting phenomena. These results show that adding nanoparticles is an efficient way to enhance the heat transfer in latent heat thermal energy storage system